Melrose Homes for Sale

Welcome to Melrose, Florida – a hidden gem nestled in the heart of the Sunshine State! Known for its charming small-town atmosphere and picturesque landscapes, Melrose offers a unique blend of tranquility and community spirit. Located just a short drive from the bustling cities of Gainesville and Palatka, this quaint town is surrounded by serene lakes and lush greenery, making it the perfect retreat for nature lovers and those seeking a peaceful lifestyle.

Melrose boasts a rich history and a vibrant community, with friendly locals who take pride in their town. The area is adorned with delightful shops, cozy cafes, and local eateries that reflect the community’s character. For outdoor enthusiasts, the nearby lakes provide ample opportunities for fishing, boating, and hiking, while the beautiful parks offer spaces for picnicking and enjoying the great Florida weather.

If you’re considering making Melrose your home, you’ll be pleased to know that there are a variety of homes for sale that cater to diverse tastes and budgets. From charming single-family homes with spacious yards to modern residences that offer contemporary amenities, Melrose has something for everyone. Whether you’re a first-time homebuyer or looking for a peaceful retirement haven, you’ll find that Melrose’s real estate market is both inviting and accessible.

Discover the warmth of Melrose, where community ties are strong, and the natural beauty is unmatched. Explore the homes for sale today and take the first step toward your dream life in this enchanting Florida town!

Newest Melrose Homes for Sale

$479,000

3 Beds ⋅ 4 Baths ⋅ 2169209 MLS

Beautiful Seminole Ridge Home! This 3 bedroom 3.5 bath home has 3093 sq ft of living space and sits on 1.6 acres in a park like setting. The home was updated in 2024 with new roof, AC, and submersible well & tank. It has a spacious great room with vaulted ceilings and tubular skylights. The kitchen has granite countertops, a large pantry, stainless steel appliances, plenty of cabinetry, breakfast bar, and a breakfast nook for casual dining. The bedrooms have walk in closets and en suite bathrooms. The bedroom adjacent to the family room could be used as an in-law suite. The laundry room has a half bath and lots of storage. There's an all purpose room off the kitchen with hot tub that leads to the screen porch and concrete patio. The home has a detached 2 carport and attached 1 car carport that connects to a workshop. The back yard has privacy fencing and a shed and the whole property is made up of three parcels, one in Bradford and two in Clay. Come and see this home will not last!

657 Se 2nd Avenue, Melrose

$265,000

3 Beds ⋅ 2 Baths ⋅ 2168751 MLS

Beautifully updated and move-in ready, this 3-bedroom, 2-bath home offers 1,829 square feet of living space in Melrose. The spacious family room features recessed lighting, large windows that bring in plenty of natural light, and plenty of room to relax, gather, or entertain. The open layout connects the family room to the dining area and updated kitchen, creating a bright and welcoming living space. The kitchen features white cabinetry, stainless steel appliances, plenty of counter space, and a large island with seating. LVP flooring runs throughout the main living areas, while both bathrooms have been beautifully updated with modern finishes and tile work. An indoor laundry room adds everyday convenience. Outside, you'll find a spacious backyard with mature trees and plenty of room to enjoy the outdoors. The home also features a 2023 roof. Conveniently located just minutes from the upcoming Aldi in Melrose, Winn-Dixie, Keystone Beach and Park, local restaurants, & everyday services.

6898 County Road 214, Melrose

$490,000

4 Beds ⋅ 3 Baths ⋅ 2168661 MLS

8042 County Line Rd is a two-story Melrose home set on a large, wooded lot shaded by mature oak trees. The kitchen features generous cabinetry and counter space, with room for casual dining. A brick fireplace anchors the living room, adding warmth and a focal point to the main level, which flows across wood-toned flooring. The primary bedroom connects to an ensuite bathroom with a soaking tub and a vanity, and several additional bathrooms serve the home. Multiple bedrooms provide flexible space for work or hobbies, and a covered walkway links outdoor areas across the grounds, rounding out this well-maintained residence. Included 100-Day Home Warranty with buyer activation

8042 County Line Road, Melrose

$399,900

3 Beds ⋅ 3 Baths ⋅ 2167055 MLS

Lakefront living with built-in income! Well-maintained home on a landscaped 1.19-acre, high-and-dry lot just minutes from downtown historic Melrose. 3 bedrooms, 3 full bathrooms (main residence is 2 bed / 2 bath, apartment is 1 bed / 1 bath), tons of storage, and an expansive screened lakefront lanai with inset hot tub! There is also a 900 sqft semi-finished basement with drywall, electrical, and plumbing. Use it for massive storage, finish it into a private office space or game room, etc. Separate built-in storage for a lawn mower or tools, plus a 1-car garage and ample driveway parking. A full efficiency apartment with kitchen, full bathroom, and laundry is currently rented for almost $1,000/mo on a month-to-month lease. Perfect passive income, in-law suite, or guesthouse. All of this in a prime location less than 30 minutes to Gainesville or Palatka and just 5 minutes from the almost 6,000-acre Lake Santa Fe public boat ramp! Welcome Home!

135 Ashley Lake Drive, Melrose

$379,000

3 Beds ⋅ 2 Baths ⋅ 2166772 MLS

Welcome to 359 SE 4th Avenue, a spacious home nestled in the desirable Seminole Ridge section of Melrose. This 3-bedroom, 2-bathroom home offers comfortable living spaces and a versatile bonus area created from the converted garage. The family room and dining area feature a cozy wood-burning fireplace, creating the perfect setting for family gatherings and entertaining. Situated on a beautiful 0.61-acre lot, the property offers natural landscaping between neighboring homes, providing added privacy and a peaceful outdoor setting. Built with concrete construction and a durable metal roof, this home offers low-maintenance living so you can spend more time relaxing and enjoying your surroundings. Recent updates include improvements to both bathrooms and new flooring throughout the main living areas. Don't miss the opportunity to make this inviting Melrose home your own. Schedule your showing today before it's gone!

359 Se 4th Avenue, Melrose

$814,900

6 Beds ⋅ 3 Baths ⋅ 2165784 MLS

Where Lake Life Meets Country Comfort 8315 Lilly Lake Road - Melrose, Florida, Imagine waking up beneath a canopy of mature oaks, spending your afternoons beside the pool, and ending the day with the peaceful beauty of private Lake Opal just beyond your door. Welcome to a truly special Melrose retreat-an expansive 4,425-square-foot brick home nestled on 1.69 acres of picturesque lakefront property. Designed for both comfortable everyday living and unforgettable gatherings, this six-bedroom, four-bath home offers the space, flexibility, and setting today's buyers are looking for. Inside, the heart of the home is the generous kitchen and inviting family spaces, where gatherings naturally become the centerpiece of everyday life. A spacious family room flows into a dedicated game room, complete with a pool table and built-in ping-pong table-creating an ideal setting for holidays, weekend guests, or simply enjoying time together. Need room for everyone? You have it. The home includes six bedrooms, the in-law suite features its own private entrance-perfect for extended family, guests, multigenerational living, or a private home office arrangement. One bedroom offers excellent flexibility as a dedicated office, study, or creative space. Storage is anything but an afterthought. A huge pantry/storage area, large laundry room with built-in drop zone and ironing board, plus additional storage beneath the pool deck provide practical solutions for everything from everyday organization to outdoor equipment. And then there is the lifestyle. Step outside and enjoy your own private oasis with a pool, hot tub, lake views, fenced yard, dog run, RV hookup, and oversized parking. Mature trees provide shade and privacy while Lake Opal creates a beautiful backdrop for quiet mornings, weekend recreation, fishing, swimming, and sunset gatherings. With a metal roof, brick exterior, private well and septic system, this property combines enduring construction with the relaxed appeal of lake-country living. Located in the Melrose/Keystone Heights area, the property offers a peaceful retreat while remaining conveniently positioned for access to Gainesville, Ocala, St. Augustine, and Jacksonville. More Than a Home-It's a Place to Gather, Unwind & Make Memories. Whether you're looking for a spacious primary residence, a multigenerational home, a private lake retreat, or simply a property where family and friends can come together, 8315 Lilly Lake Road offers an uncommon combination of space, privacy, recreation, and waterfront living. In Law Suite is included in the 4425 SF. Come experience Lake Opal living for yourself.

8315 Lilly Lake Road, Melrose

$599,999

3 Beds ⋅ 2 Baths ⋅ 2166572 MLS

WATERFRONT LIVING ON THE CANAL TO LAKE SANTA FE! This spacious 3-bedroom, 2-bath waterfront home offers 2,301 square feet of heated and cooled living space with an ideal blend of comfort, functionality, and outdoor living. The interior features a welcoming living room, dedicated office area, dining space, and a well-appointed kitchen with prep island—perfect for everyday living and entertaining. The oversized primary bedroom is truly impressive, measuring approximately 31 feet in length and offering plenty of room to relax and unwind. Step outside to the lanai and take in peaceful waterfront views overlooking the boat house and boat lift. The outdoor living area is designed for enjoying the Florida lifestyle, featuring an inviting in-ground pool and hot tub. With canal access to Lake Santa Fe, this property offers an exceptional opportunity for boating, recreation, and waterfront enjoyment right at home. A unique combination of spacious indoor living, private outdoor amenities, and direct water access makes this Lake Santa Fe-area home a must-see.

241 Se 5th Avenue, Melrose

$175,000

2 Beds ⋅ 3 Baths ⋅ 2166324 MLS

New price reflects seller's intent to sell quickly — bring your best offer! Escape to tranquility at 134 Serenity Drive, Melrose, FL! Nestled in a quiet setting along the lakefront, this unique property offers incredible upside for the right buyer. The listing includes two separate structures: a main house with 1 bedroom and 1.5 bathrooms, plus a private cottage with 1 bedroom and 1 bathroom. A great starter project to renovate, replace, or customize into your dream home or rental income generator. Convenient location with rural charm. Sold as-is; cash or conventional rehab financing preferred.

134 Serenity Drive, Melrose

$549,000

3 Beds ⋅ 2 Baths ⋅ 2165461 MLS

A rare opportunity to enjoy 12 acres and your own private lake setting! This updated 3-bedroom, 2-bath home offers 1,656 sq ft surrounded by beautiful oaks, mature woods, and abundant wildlife including deer and turkey. The property sits on crystal-clear, sand-bottom Opal Lake, reaching approximately 40 feet deep and offering excellent fishing right outside your door. Inside, the home features luxury vinyl plank flooring, modern finishes, shiplap accents, and tongue-and-groove ceilings that add warmth and character throughout. Step outside to a large back deck with plenty of room for entertaining, relaxing, or taking in the peaceful surroundings. An outdoor shower is perfect for rinsing off after working around the property or spending the day at the lake. With 12 acres, privacy, wildlife, and private lake access, this property delivers the North Florida lifestyle that's getting harder to find.

8189 Melrose Road, Melrose

$398,000

2 Beds ⋅ 2 Baths ⋅ 2164259 MLS

Nestled on Island Road in Melrose, escape to your private waterfront oasis on the desirable Santa Fe Canal, with direct access to the expansive 6,000-acre Santa Fe Lake. This beautifully updated 2-bedroom, 2-bath home blends indoor comfort with outdoor Florida living-all just minutes from a public boat ramp and picnic area. Detached 2-car garage for storage, projects, or extra parking. Sprinkler system keeps the landscape lush with minimal effort. Canal-side deck ideal for cookouts, fishing, or relaxing by the water. Recent major updates: HVAC (2023), water heater (2024) plus many more recent improvements throughout. Vaulted ceiling with a stone-accent gas fireplace creates a warm, open great room. Split bedroom floor plan for privacy and flexibility. Enclose sunroom-perfect for morning coffee or enjoying outdoors from inside.

5930 Island Road, Melrose

$795,000

4 Beds ⋅ 2 Baths ⋅ 2161072 MLS

Modern farmhouse charm meets wide-open country living on 13 beautiful acres in Melrose! Originally built in 2004, this home has been thoughtfully renovated from top to bottom, all while preserving the character that makes this home special and unique. Prepare to fall in love with the sky high vaulted ceilings, refinished original hardwood floors, and exquisite wood trim surrounding the windows and doors, truly bringing home the cozy farmhouse charm. Warm neutral interior paint decks the walls, emphasizing the natural wood tones found throughout the home, while bright white baseboards, new light fixtures and ceiling fans, and stylish matte black hardware add a clean, modernized aesthetic. The completely refreshed kitchen features stunning quartz countertops, a trendy drop-in sink, gas range, stainless steel appliances, refinished custom original wood cabinetry, and a gorgeous herringbone backsplash. There's plenty of room to sprawl out with a bonus room off of the foyer, and stairs leading to an impressively sized loft above. Decorative sconce lighting leads down the hallway to a massive primary suite, truly a retreat in its own right, featuring a beautifully updated bath with a tiled walk-in shower, soaking tub, and a porcelain dual vanity. Outside, this expansive 13 acre property offers privacy, peace, serenity, and whatever your heart desires. A charming red barn sits adjacent to the home, and with AG zoning can be turned into a refuge for livestock or storage for boats, ATV's, or any other toys you can think of! An additional water, sewer, and electric hook-up offered on the property will make it a breeze to add an a guest house or full utility workshop, etc. This property is truly one of a kind, don't miss your opportunity to schedule a tour TODAY!

146 Mallard Road, Melrose

$759,500

3 Beds ⋅ 2 Baths ⋅ 2159365 MLS

Looking for the perfect small horse farm with a remodeled home, barn, tack room, and plenty of fenced acreage? Your search is over! Come see this beautifully remodeled 3-bedroom, 2-bathroom brick home situated on 3.14 acres in the heart of beautiful Melrose, Florida. Designed with the horse lover in mind, this property is completely fenced and cross-fenced and is ready for you and your horses to move right in! The property features a brand-new 3-stall barn, complete with a half bath and tack room. In Addition, Two out buildings provide more storage and workspace. Inside the home, you'll find extensive updates throughout, including brand-new Pella windows, two beautifully renovated bathrooms, and a new kitchen. The screened lanai provides a wonderful space to enjoy the peaceful surroundings year-round. After a long day of riding or working around the farm, unwind in your heated outdoor swim spa--the perfect place to relax and enjoy your own private piece of Florida horse countr

135 Pearsall Circle, Melrose

Start Your Search

The data relating to real estate listings on this website comes in part from the Internet Data Exchange (IDX) program of Multiple Listing Service of Southern Arizona. IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Listings provided by brokerages other than Integrity One Properties are identified with the MLSSAZ IDX Logo. All Information Is Deemed Reliable But Is Not Guaranteed Accurate. Listing information Copyright 2026 MLS of Southern Arizona. All Rights Reserved.

Melrose Homes for Sale

Newest Melrose Homes for Sale

How much is your home worth?

How much is your home worth?